NEOANTIGEN ARCHITECTURES DEFINE IMMUNOGENICITY AND DRIVE IMMUNE EVASION OF TUMORS WITH HETEROGENOUS NEOANTIGEN EXPRESSION

Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are Medical and Ambulatory supplies / Nutritionals and Feeding Supplies associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preven

Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, requires an immediate anticoagulation, that has been carried out so far by administering a parenteral anticoagulant drug (heparin or derivatives) overlapped with an oral vitamin K antagonist (VKA), more often warfarin.Several new Chopper direct oral anticoagulan